Does CBD Oil Work for Migraines?

Does CBD Oil Work for Migraines?

CBD Oil for Migraines

Toward the conclusion for the century that is 19th cannabis had been a main-stream treatment for preventing and relieving migraines along with other forms of headaches. Numerous health practitioners advocated becausage of its use before the 1940s, when cannabis was taken from the official pharmacopeias due to its “high possibility of abuse” 1+, 2.

The legalization that is recent of marijuana and CBD oil in many countries worldwide revived the almost-forgotten utilization of cannabis for headaches. But, it is crucial to notice that the actual only real medical utilization of CBD approved by the Food And Drug Administration is always to reduce seizures in 2 forms of epilepsy 3.

Migraines along with other kinds of headaches are, after joint disease, the painful conditions most commonly enhanced with CBD oil. In a study on 1500 medical CBD users, about one away from six reported struggling with headaches 4.

30% of medical cannabis users reported doing so to alleviate migraines as well as other headaches in 2 studies on very nearly 2500 individuals. However, the absolute most variety that is popular them was “OG Shark,” a THC-rich hybrid strain with a low CBD content 5, 6.

This renders us utilizing the concern: does CBD oil alone relieve migraines and other forms of headaches or do you need to just take THC-containing cannabis strains getting the pain-relieving advantages? Let’s look at the technology of CBD first to obtain the responses.

How Exactly Does It Work?

Regardless of type, headaches include an overactivation of nerves attached to arteries in the brain (trigeminovascular system) 2, 7+.

Released proteins that are vessel-wideningCGRP and substance P) and messengers (NO) enhance blood circulation, which stimulates discomfort receptors on neurological cells within the mind and throat. Headaches really are a result that is direct of stimulation, while drugs for headaches usually block these receptors 2, 7+.

Boosts Natural Cannabinoids

The endocannabinoid system is consists of two receptors: CB1 and CB2. Both THC from cannabis additionally the cannabinoids obviously created by the human body, such as for example anandamide, relieve pain by activating these receptors 8, 10, 11.

CBD differs from the others: it blocks as opposed to activates these receptors. Nevertheless, it prevents anandamide from being divided. Interestingly, a theory through the very early twenty-first century connected migraines (along with other chronic discomfort conditions) with low anandamide levels 12, 10, 13, 14, 15.

In reality, further studies revealed that individuals – and especially women – with migraines often have less anandamide within the spinal fluid and platelets 16, 17, 18.

Exactly the same ended up being true in people who have headaches from overusing painkillers; when they withdrew through the medications, that they had less anandamide breakdown and discomfort 19, 20.

Individuals with chronic headaches have actually reduced anandamide levels and greater CGRP and NO production. CB1 activation by anandamide and cannabinoids that are synthetic the creation of CGRP with no, which prevents (trigeminovascular) neurological overstimulation and headaches 21, 22, 23, 24, 16.

Activates Serotonin Receptors

As hinted above, anandamide reduces migraines by activating CB1. In rats, blockers associated with the serotonin receptor 5HT(1B/1D) prevented anandamide from activating CB1. This receptor includes a well-known part in relieving headaches and its own activators (called triptans) are traditional drugs for migraines 25, 26, 27.

CBD may reduce neurological pain by activating another serotonin receptor (5HT1A), which will be based in the back instead of when you look at the mind 28|relative head28, 29, 30, 31.

Activates the TRPV1 Receptor

CBD and anandamide can bind to a receptor tangled up in inflammatory pain (TRPV1). Its activation causes the production of CGRP, which increases the flow of blood towards the trigeminal nerves. This shows that CBD could cause headaches 14, 32, 33, 34, 35.

Nonetheless, repeated TRPV1 activation reduces sensitivity to pain. Certainly, a nose spray aided by the chili pepper compound capsaicin – which also activates this receptor – relieved migraines in a trial that is small 8 individuals 14, 36+.

Obstructs Glutamate

Alterations in vision, mobility, or message called aura typically precede migraine assaults. These harbingers that are migraine brought on by glutamate overactivation into the mind. Anandamide, THC, and artificial cannabinoids block glutamate receptors, suggesting they assist in preventing auras 2, 37, 38, 39, 40.

Reduces Inflammation and Autoimmunity

Autoimmune conditions may trigger migraines as well as other forms of headaches when they result irritation associated with arteries into the mind. Certainly, conditions such as numerous sclerosis, lupus, Sjцgren syndrome, and syndrome that is antiphospholipid related to regular headaches 41.

CBD may relieve headaches in people who have these conditions through its strong activity that is anti-inflammatory. It reduces the production of pro-inflammatory messengers (such as for instance IL-1beta, IL-6, TNF-alpha, IFN-gamma. NO, and prostaglandins) while increasing the amounts of the cytokines that are anti-inflammatory and IL-10 43, 44, 45, 46, 47.

Instead, it could avoid the outward indications of autoimmune disorders by curbing the immune reaction. As an example cbd oil, CBD prevented T cells from building and multiplying up when you look at the minds of mice with multiple sclerosis – while reducing the autoimmune-linked Th17 reaction 48, 49.

Whenever Does It Work?


In a report on over 100 people who have migraines making use of medicinal cannabis (with both CBD and THC), 85% reported paid down pain and frequency 50 that is migraine.

In a medical test on 79 people who have chronic migraines, a preparation with additional CBD than THC prevented assaults as effectively as a migraine drug (amitriptyline). a dose that is additional the assaults paid off pain. Likewise, 3 hefty cannabis cigarette smokers began having migraines once they stopped; one got respite from smoking once again 51.

THC may account fully for a part that is great of impacts. THC alone prevented attacks that are migraine paid off pain in rats. In comparison, its overuse could have the contrary effect: high doses increased sensitivity to duplicated neurological stimulation – a suspected migraine trigger 53, 54.

Taken together, there's absolutely no proof that CBD oil improves migraines. Studies in rats even suggest that THC instead of CBD could be the cannabinoid accountable for the pain sensation relief seen in individuals cannabis that are using for migraines.

Other Types of Headaches

In a scholarly research on over 100 individuals with group headaches, 45% utilized cannabis but only 25% skilled relief while 22percent felt even even worse 55.

In a single report, leisure marijuana and synthetic THC (dronabinol) enhanced regular cluster headaches in a teen. The advantage had been most most likely from THC, maybe not CBD 56.

In an effort on 13 people who have headaches from overusing painkillers, cannabis preparations reduced pain. Nonetheless, the planning with all the greatest THC content (oil) was more efficient. In accordance with this, an artificial THC substance (nabilone) reduced discomfort and also the importance of painkillers a lot better than ibuprofen in another trial on 26 individuals 57, 58.

Into the term that is short THC as well as other CB1 activators also relieved headaches from painkillers in rats. Nonetheless, their duplicated use increased sensitiveness to pain – meaning it might trigger migraines 54.

Both marijuana that is medical an artificial THC element (dronabinol) relieved headaches in 2 females with a high force into the brain (pseudotumor cerebri) 59+, 60.

Several clinical and animal studies recommend that CBD is possibly inadequate for cluster headaches and headaches from overusing painkillers. THC is apparently the cannabinoid that is only some pain alleviation, nevertheless the proof remains limited.


There aren't any clinical studies CBD that is testing alone headaches. Many of them utilized cannabis preparations with adjustable quantities of THC and CBD.

Many people with migraines prefer THC-rich cannabis strains. Plus, synthetic THC analogs had been also effective. This implies that migraine relief requires direct activation that is CB1 only THC will probably attain. Having said that, CBD may somewhat assist by boosting anandamide levels.

CBD Oil Dosage for Migraines


Because CBD just isn't authorized for migraines or just about any other forms of headaches, there is absolutely no dose that is official. There's no proven dosage either because CBD alone hasn’t been tested in medical studies. The only research evaluating an item greater in CBD than in THC (9% vs 0.4%) utilized a dosage of 200 mg (supplying 18 mg CBD) a day. But, we can’t rule the contribution out of its THC content to your results 51+.

We could furthermore calculate dosage on the basis of the recommendations from manufacturers and users.

One maker of the commercial oil specifically formulated for migraines recommends 1 mL (supplying 33 mg CBD) per day.

Natural wellness blogs and users prefer lower doses (15-25 mg/day). They often recommend beginning with a low dosage and increasing it until observing pain-relieving results. It’s important to get this done gradually, since high doses may trigger migraines while increasing hassle intensity 61.

Whatever the case, don’t try CBD oil or other unverified treatments for migraines and headaches without consulting your physician ahead of time. Check with the doctor if CBD oil can help available for you and exactly exactly what dose and form that is delivery be much better for your needs.

Just how to make use of

CBD oil is available in various types. Your as a type of option might depend on your sort of frustration 62+:

  • Vaping, lips sprays, and oil tinctures are consumed quickly and offer pain relief that is temporary. They may operate better for cyclically-arising headaches such as for example group headaches.
  • Capsules, edibles, and teas discharge the CBD more gradually but their effects go longer. They may be better for conditions with constant discomfort such as for example headaches from overusing painkillers.

Although migraine discomfort is certainly not constant, slow-release CBD types might be more efficient (according to CBD’s conversation using the TRPV1 receptor). Acute CBD doses may trigger migraine assaults while duplicated doses decrease pain perception.

Anecdotal proof from internet forums advises using medicinal cannabis services and products just after beginning to sense the start of a migraine or cluster hassle attack 61.

Most readily useful CBD Oil for Migraines

As well as selecting a CBD oil modified to your allowance (you may want to determine the purchase price per mL or mg to compare brands that are different, its also wise to measure the product quality. Read here on how to pick the best CBD oil.


The opinions indicated in this part are entirely those of CBD oil users who may or might not have medical or training that is scientific. Their reviews try not to express the views of SelfHacked. SelfHacked will not endorse any certain item, solution, or therapy.

Usually do not consider individual experiences as medical advice. Never ever wait or disregard seeking expert medical advice from your physician or any other qualified health care providers as a result of one thing you've got keep reading SelfHacked. We realize that reading individual, real-life experiences could be a helpful resource, however it is never ever a replacement for professional medical advice, diagnosis, or therapy from a qualified doctor.

The absolute most typical hassle type among CBD oil users ended up being migraine, followed by stress hassle, and hassle from painkiller overuse or conditions such as for instance fibromyalgia. Many of them were pleased and reported good pain alleviation. The users reported some added benefits such as improving sleep quality and curbing anxiety in several cases.

Some users complained that the oil didn’t work that it made them drowsy and fatigued for them or. CBD oil even caused headaches in a few individuals using it at high doses.


Many people with migraines utilize THC-rich cannabis strains, although some prefer CBD oil. No studies that are clinical yet tested CBD oil alone for headaches or migraines.

Animal studies reveal that CBD oil may relieve headaches – but just when you look at the long haul and most likely not along with THC.

Sudden spikes in CBD, such as for example from vaping, could cause migraines. But taken long-lasting, CBD may decrease pain perception and avoid migraine auras. It mainly functions boosting your cannabinoid that is natural bliss.

CBD oil can also be an alternative if you have migraines and headaches from autoimmune diseases like lupus and sclerosis that is multiple. In these instances, it probably helps by reducing mind suppressing and inflammation autoimmunity.

Opt for capsules or edibles and just simply take them every day for the very best outcomes.

Vendors offer CBD oil on Amazon, however, many of those don't fulfill quality criteria. Some don’t even specify the CBD content inside their services and products, while other people offer hemp oil with little to no or no CBD. A lot of these vendors are to not ever be trusted.

We suggest the following brand name, which specifies quality procedures and CBD content inside their items:

This area contains sponsored links, which means that we possibly may get a tiny portion for the earnings from your own purchase, even though the price continues to be the same to you personally. The arises from your purchase help our work and research. Many thanks for your help!